A multiplex cytokine score for the prediction of disease severity in pediatric hematology/oncology patients with septic shock.

Highlights: [•] We develop a multiplex cytokine model named PMCS to evaluate septic shock. [•] PMCS integrates four inflammatory cytokines: IL-6, IL-10, TNF-α and IFN-γ. [•] PMCS correlates well with hemodynamic disorder and mortality in septic shock. [•] PMCS improves severity and mortality prediction compared with individual cytokines. [•] PMCS presents similar discriminative power on fatal outcome with PIM2. [Copyright &y& Elsevier]