Clinical significance of both tumor and stromal expression of components of the IL-1 and TNF-α signaling pathways in prostate cancer.

Highlights: [•] IL-1 and TNF-α have been involved in cancer initiation and progression. [•] Studies on the value of TNF-α and IL-1 as predictors have focused on alleles or serum levels. [•] We studied the prognostic value of expression of IL-1/TNF-α signaling components for prostate cancer. [•] TNF-α/IL-1β signaling proteins predicted clinical outcome in prostate cancer. [Copyright &y& Elsevier]