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Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation.
- Source :
-
International Journal of Nephrology . 2011, p1-6. 6p. 4 Charts, 4 Graphs. - Publication Year :
- 2011
-
Abstract
- Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF- 23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANALYSIS of variance
*CELL adhesion molecules
*STATISTICAL correlation
*ENZYME-linked immunosorbent assay
*GROWTH factors
*MULTIVARIATE analysis
*NONPARAMETRIC statistics
*RESEARCH funding
*STATISTICS
*T-test (Statistics)
*U-statistics
*LOGISTIC regression analysis
*DATA analysis
*DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 2090214X
- Database :
- Academic Search Index
- Journal :
- International Journal of Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 90561076
- Full Text :
- https://doi.org/10.4061/2011/297070