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Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.

Authors :
Pan, Yanfang
Zhang, Jing
Liu, Wei
Shu, Pengcheng
Yin, Bin
Yuan, Jiangang
Qiang, Boqin
Peng, Xiaozhong
Source :
Neuroscience Letters. Oct2013, Vol. 553, p46-51. 6p.
Publication Year :
2013

Abstract

Highlights: [•] The expression of Dok5 gradually declines during the development of dorsal root ganglia. [•] Dok5 interacted with TrkC and colocalized with TrkC in DRG neurons. [•] Dok5 is necessary in the NT-3 signaling pathway that reduces TrkC-induced apoptosis [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043940
Volume :
553
Database :
Academic Search Index
Journal :
Neuroscience Letters
Publication Type :
Academic Journal
Accession number :
90525159
Full Text :
https://doi.org/10.1016/j.neulet.2013.08.006