The synthesis of 2-ketopiperazine acetic acid esters and amides from ethylenediamines with maleates and maleimides

Authors :: Abelman, Matthew M.
Fisher, Karl J.
Doerffler, Edward M.
Edwards, Paul J.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Feb2003, Vol. 44 Issue 9, p1823. 4p.
Publication Year :: 2003
Abstract: The reaction of substituted ethylenediamines with various fumarates, maleates, and maleimides to form substituted ketopiperazine acetic acid esters and amides was investigated. This method affords a straightforward, high yield approach to a variety of potential peptidomimetics and can yield surprising results with regard to regio- and stereoselectivity. [Copyright &y& Elsevier]

Language :: English
ISSN :: 00404039
Volume :: 44
Issue :: 9
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 9050781
Full Text :: https://doi.org/10.1016/S0040-4039(03)00103-5

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