Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets.

Authors :: Maedler, Kathrin
Sergeev, Pavel
Ris, Frederic
Oberholzer, Jose
Joller-Jemelka, Helen I.
Spinas, Giatgen A.
Kaiser, Nurit
Halban, Philippe A.
Donath, Marc Y.
Source :: Journal of Clinical Investigation. 9/15/2002, Vol. 110 Issue 6, p851. 10p. 3 Color Photographs, 1 Black and White Photograph, 1 Chart, 2 Graphs.
Publication Year :: 2002
Abstract: Focuses on a study that tested the hypothesis that IL-β may mediate the deleterious effects of high glucose on human β cells. Procedures used in the isolation and culture of islets; ELISA kits used in the evaluation of cytokine release; Identification of the islet cellular source of glucose-dependent IL-1β production.

Subjects :: *GLUCOSE
*PANCREATIC beta cells
*ISLANDS of Langerhans
*CYTOKINES

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