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Determination of Prostaglandin E1 in dog plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study.
- Source :
-
Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences . Oct2013, Vol. 937, p97-102. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] An LC–MS/MS was developed and validated for the determination of PGE1 in beagle dog plasma. [•] An LLOQ of 10pg/mL was achieved. [•] Indomethacin was added to plasma to avoid significant endogenous interfere. [•] A simple one-step sample extraction was used followed by a short cycle time of 3min. [•] The method was applied to a pharmacokinetic study in dogs at a clinical relevant dose. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15700232
- Volume :
- 937
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 90312698
- Full Text :
- https://doi.org/10.1016/j.jchromb.2013.08.021