Back to Search Start Over

Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging.

Authors :
Cheng, Cheng-Chieh
Chiu, Su-Chin
Jen, Yee-Min
Chang, Hing-Chiu
Chung, Hsiao-Wen
Liu, Yi-Jui
Chiu, Hui-Chu
Chen, Cheng-Yu
Huang, Guo-Shu
Juan, Chun-Jung
Source :
Magnetic Resonance Imaging (0730725X). Oct2013, Vol. 31 Issue 8, p1278-1284. 7p.
Publication Year :
2013

Abstract

Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9±3.9Gy with a PSV of 43.1%±13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower K el, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. K el and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0730725X
Volume :
31
Issue :
8
Database :
Academic Search Index
Journal :
Magnetic Resonance Imaging (0730725X)
Publication Type :
Academic Journal
Accession number :
90204190
Full Text :
https://doi.org/10.1016/j.mri.2013.03.018