Human lymphocyte repertoires in ageing.

Highlights: [•] B and T cell numbers, subsets, and antigen receptor repertoires change with age. [•] There is evidence that CD27−IgD− B memory cells increase with age. [•] Variance in Ig diversity estimates is still very high with current data sets. [•] Preliminary data indicate that IgM+ B cells with long IGH CDR3 may increase with age. [•] Vaccine response and repertoires are beginning to be reported. [ABSTRACT FROM AUTHOR]