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Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: The experience of the “Rete Ematologica Lombarda”.
- Source :
-
Leukemia Research . Oct2013, Vol. 37 Issue 10, p1233-1240. 8p. - Publication Year :
- 2013
-
Abstract
- Abstract: To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the “Rete Ematologica Lombarda”. According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01452126
- Volume :
- 37
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Leukemia Research
- Publication Type :
- Academic Journal
- Accession number :
- 90093760
- Full Text :
- https://doi.org/10.1016/j.leukres.2013.07.006