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Celiac disease: A disease with varied manifestations in adults and adolescents.

Authors :
Sharma, Minakshi
Singh, Prashant
Agnihotri, Abhishek
Das, Prasenjit
Mishra, Asha
Verma, Anil K
Ahuja, Arvind
Sreenivas, Vishnubhatla
Khadgawat, Rajesh
Gupta, Siddhartha Datta
Makharia, Govind K
Source :
Journal of Digestive Diseases. Oct2013, Vol. 14 Issue 10, p518-525. 8p. 5 Charts, 1 Graph.
Publication Year :
2013

Abstract

Objective We aimed to determine the characteristics of patients with celiac disease and differences between those who presented during adolescence or adulthood. Methods We retrospectively reviewed the case records of 233 consecutive patients with celiac disease who were diagnosed at 12-18 years or >18 years of age. The diagnosis of celiac disease was made on the basis of the modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition criteria. Results The diagnosis of celiac disease was made after 18 years of age in 153 (65.7%) patients. Median duration of symptoms at the diagnosis was 54 months (range 1 month to 29 years). In all, 103 (44.2%) patients with atypical manifestations were referred by other departments for evaluation. Chronic diarrhea (48.5%), short stature (27.0%) and chronic anemia (9.0%) were the common modes of presentation. Elevated level of aminotransaminase were present in 50 (24.3%) patients. Chronic diarrhea, hypocalcemia and hypoalbuminemia were present in significantly higher number of adult than adolescent patients. In all, 227 (97.4%) patients responded to a 6-month gluten-free diet and six non-responders were non-compliant. Conclusions More than 40% of the patients with celiac disease present to clinicians other than gastroenterologists or internists with atypical manifestations. A high index of suspicion is required for diagnosing its variant forms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17512972
Volume :
14
Issue :
10
Database :
Academic Search Index
Journal :
Journal of Digestive Diseases
Publication Type :
Academic Journal
Accession number :
90054544
Full Text :
https://doi.org/10.1111/1751-2980.12078