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Microcystin-LR inhibited hippocampal long-term potential via regulation of the glycogen synthase kinase-3β pathway.

Authors :
Wang, Jianghua
Lin, Fankai
Cai, Fei
Yan, Wei
Zhou, Qiong
Xie, Liqiang
Source :
Chemosphere. Sep2013, Vol. 93 Issue 2, p223-229. 7p.
Publication Year :
2013

Abstract

Highlights: [•] MCLR significantly impaired LTP in a concentration-dependent manner. [•] GSK-3β inhibitors prevents the effects of MCLR on hippocampal LTP in vivo. [•] MCLR increased the activity of GSK-3β via regulating phosphorylation at Ser9 site. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00456535
Volume :
93
Issue :
2
Database :
Academic Search Index
Journal :
Chemosphere
Publication Type :
Academic Journal
Accession number :
90006954
Full Text :
https://doi.org/10.1016/j.chemosphere.2013.04.069