Anticancer cyclometalated complexes of platinum group metals and gold.

Authors :: Cutillas, Natalia
Yellol, Gorakh S.
de Haro, Concepción
Vicente, Consuelo
Rodríguez, Venancio
Ruiz, José
Source :: Coordination Chemistry Reviews. Oct2013, Vol. 257 Issue 19/20, p2784-2797. 14p.
Publication Year :: 2013
Abstract: Highlights: [•] Cyclometalated complexes of noble metals are promising anticancer prodrugs. [•] These compounds show improved stability and enhanced cytotoxicity. [•] Cyclometalated compounds are suitable for rational drug design. [•] Besides DNA, protein/enzyme interactions represent a major mode of action. [Copyright &y& Elsevier]