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HLA specificities are related to development and prognosis of diffuse large B-cell lymphoma.

Authors :
Alcoceba, Miguel
Sebastian, Elena
Marin, Luis
Balanzategui, Ana
Eugenia Sarasquete, M.
Carmen Chillon, M.
Jimenez, Cristina
Puig, Noemi
Corral, Rocfo
Pardal, Emilia
Grande, Carlos
Bello, Jose Luis
Albo, Carmen
Cruz, Fatima de la
Panizo, Carlos
Martin, Alejandro
Gonzalez-Barca, Eva
Dolores Caballero, M.
San Miguel, Jesus F.
Garcia-Sanz, Ramon
Source :
Blood. 8/22/2013, Vol. 122 Issue 8, p1448-1454. 7p.
Publication Year :
2013

Abstract

Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease influenced by genetic and environmental factors. The role of the HLA system in tumor antigen presentation could be involved in susceptibility and disease control. We analyzed the phenotypic frequencies of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 in 250 DLBCLs, comparing them with 1940 healthy individuals. We also evaluated the influence of HLA polymorphisms on survival in those patients treated with curative intention using cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-like regimen without (n = 64, 26%) or with (n = 153, 61%) rituximab. DLBCL patients have a higher phenotypic frequency of HLA-DRB1 "01 (29% vs 19.5%, P = .0008, Pc = .0104) and a lower frequency of HLA-C"03 (6.4% vs 17.9%, P < .0005, Pc = .007) compared with healthy individuals. Irrespective of the age-adjusted International Prognostic Index, those patients receiving a CHOP-like plus rituximab regimen and carrying the HLA-B44 supertype had worse 5-year progression-free (54% vs 71%, P= .019) and 5-year overall (71 %vs 92%, P= .001) survival compared with patients without this supertype. Our data suggest that some HLA polymorphisms influence the development and outcome of DLBCL, allowing the identification of an extremely good-risk prognostic subgroup. However, these results are preliminary and need to be validated in order to exclude a possible population effect. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00064971
Volume :
122
Issue :
8
Database :
Academic Search Index
Journal :
Blood
Publication Type :
Academic Journal
Accession number :
89978561
Full Text :
https://doi.org/10.1182/blood-2013-02-483420