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Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
- Source :
-
Nature Immunology . Sep2013, Vol. 14 Issue 9, p937-948. 12p. 1 Color Photograph, 7 Graphs. - Publication Year :
- 2013
-
Abstract
- Defense against attaching-and-effacing bacteria requires the sequential generation of interleukin 23 (IL-23) and IL-22 to induce protective mucosal responses. Although CD4+ and NKp46+ innate lymphoid cells (ILCs) are the critical source of IL-22 during infection, the precise source of IL-23 is unclear. We used genetic techniques to deplete mice of specific subsets of classical dendritic cells (cDCs) and analyzed immunity to the attaching-and-effacing pathogen Citrobacter rodentium. We found that the signaling receptor Notch2 controlled the terminal stage of cDC differentiation. Notch2-dependent intestinal CD11b+ cDCs were an obligate source of IL-23 required for survival after infection with C. rodentium, but CD103+ cDCs dependent on the transcription factor Batf3 were not. Our results demonstrate a nonredundant function for CD11b+ cDCs in the response to pathogens in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 14
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 89807002
- Full Text :
- https://doi.org/10.1038/ni.2679