Indigofera suffruticosa Mill extracts up-regulate the expression of the π class of glutathione S-transferase and NAD(P)H: quinone oxidoreductase 1 in rat Clone 9 liver cells.

Highlights: [•] To investigate I. suffruticosa extracts on expression of GSTP and NQO1 in hepatocytes. [•] Suffruticosa extracts increased GSTP and NQO1 levels and GSTP promoter activity in hepatocyte. [•] Suffruticosa extracts up-regulated binding affinity of Nrf2 with GPEI and ARE activation. [•] ERK inhibitor abolished I. suffruticosa extracts induced GSTP and NQO-1 expression. [•] Suffruticosa extracts increased GSH levels in mouse liver, RBC and hepatocytes. [ABSTRACT FROM AUTHOR]