Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness.

Authors :: Henderson, Rogene F
Barr, Edward B
Blackwell, Walter B
Clark, Connie R
Conn, Carole A
Kalra, Roma
March, Thomas H
Sopori, Mohan L
Tesfaigzi, Yohannes
Ménache, Margaret G
Mash, Deborah C
Dokladny, Karol
Kozak, Wieslaw
Kozak, Anna
Wachulec, Maceij
Rudolph, Karin
Kluger, Matthew J
Singh, Shashi P
Razani-Boroujerdi, Seddigheh
Langley, Raymond J
Source :: Toxicology & Industrial Health. 2001, Vol. 17 Issue 5-10, p294-297. 4p.
Publication Year :: 2001
Abstract: Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas. [ABSTRACT FROM AUTHOR]

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