LRIG1 dictates the chemo-sensitivity of temozolomide (TMZ) in U251 glioblastoma cells via down-regulation of EGFR/topoisomerase-2/Bcl-2.

Highlights: [•] TMZ resistant U251 cells express low LRIG1, but high levels of EGFR/Topo-2/Bcl-2. [•] U251 cells with LRIG1 overexpression are hyper-sensitive to TMZ. [•] U251 cells with LRIG1 knocking-down are resistant to TMZ. [•] EGFR-mTOR activation is important for Topo-2/Bcl-2 expression and TMZ resistance. [•] Topo-2/Bcl-2 inhibition or depletion restores TMZ sensitivity in resistant U251 cells. [ABSTRACT FROM AUTHOR]