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Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: A novel mechanistic insight into progressive obesity.
- Source :
-
Molecular & Cellular Endocrinology . Sep2013, Vol. 377 Issue 1/2, p123-134. 12p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Increased plasma PEDF was accompanied with reduced adipose ATGL protein and enhanced lipolysis. [•] PEDF downregulated adipose ATGL protein and upregulated lipolysis. [•] Endogenous ATGL was decreased by PEDF treatment. [•] PEDF promoted ATGL degradation via ubiquitin-dependent proteasomal degradation pathway. [•] PEDF stimulated lipolysis via ATGL activation. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03037207
- Volume :
- 377
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Molecular & Cellular Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 89607539
- Full Text :
- https://doi.org/10.1016/j.mce.2013.07.001