Effect of Mechanochemical Treatment on Physicochemical and Antitumor Properties of Betulin Diacetate Mixtures with Arabinogalactan.

It was shown using gel-permeation chromatography that arabinogalactan in a SPEX 8000 ball mill changed its molecular-weight distribution (MWD) after mechanochemical treatment. The presence of betulin diacetate assisted the reduction of the MWD after dissolution of the mechanically activated mixture in water and evaporation of the solvent. Complexes of betulin diacetate with arabinogalactan were also obtained as thin films that were readily soluble in water. Mechanical composites of arabinogalactan with betulin diacetate were capable of inducing cell elimination processes mediated by disruption of ionic homeostasis in Ehrlich ascites carcinoma cells. [ABSTRACT FROM AUTHOR]