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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
- Source :
-
Progress in Neurobiology . Jul2013, Vol. 106-107, p33-54. 22p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Autophagic degradation is impaired in the neurons of AD brain. [•] Impaired autophagy affects mitochondrial clearance and APP processing. [•] Beclin 1/Vps34 complex is the major inducer of autophagy. [•] Beclin 1 function is disturbed in AD brains and transgenic AD mice. [•] Mechanisms impairing the function of Beclin 1 interactome in AD will be discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03010082
- Volume :
- 106-107
- Database :
- Academic Search Index
- Journal :
- Progress in Neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 89510817
- Full Text :
- https://doi.org/10.1016/j.pneurobio.2013.06.002