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Pharmacokinetics and distribution of ceftazidime to milk after intravenous and intramuscular administration to lactating female dromedary camels (Camelus dromedarius).
- Source :
-
Journal of the American Veterinary Medical Association . 8/1/2013, Vol. 243 Issue 3, p424-429. 6p. - Publication Year :
- 2013
-
Abstract
- Objective-To determine the plasma disposition kinetics, absolute bioavailability, and milk concentrations of ceftazidime in healthy lactating female dromedary camels (Came/us dromedarius) following IV and IM administration of a single dose of 10 mg/kg (4.5 mg/lb) . Design-Prospective crossover study. Animals-8 healthy adult lactating fema le dromedary camels. Procedures-Camels received ceftazidime (10 mg/kg) IV and IM in a crossover study design with a 15-day washout period between treatments. Plasma and milk samples were collected at predetermined times for 48 hours after drug administration and analyzed by use of high-performance liquid chromatography. Results-A 2-compartment open model best represented the plasma concentration-versus- time data after IV and IM administration of ceftazidime to camels. Plasma ceftazidime concentrations decreased biexponentially after IV administration with mean distribution and elimination half-lives of 0.3 hours and 2.85 hours, respectively. After IM administration, the mean maximum plasma concentration of ceftazidime was 32.43 IJ.g/ml (1.21 hours after administration). mean elimination half-life was 3.20 hours, mean residence time was 4.84 hours, and mean systemic bioavailability was 93.72 %. Distribution of ceftazidime from plasma to milk was rapid and extensive as indicated by the ratio of the area under the milk concentration-versus-time curve to the area under the plasma concentration-versus-time curve and the ratio of the maximum milk concentration to the maximum plasma concentration of ceftazidime after IV and IM administration. Conclusions and Clinical Relevance-Results suggested that ceftazidime may be a useful treatment for female camels with mastitis caused by susceptible microorganisms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00031488
- Volume :
- 243
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 89473751
- Full Text :
- https://doi.org/10.2460/javma.243.3.424