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Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.
- Source :
-
Biochemical & Biophysical Research Communications . Aug2013, Vol. 437 Issue 3, p368-373. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Ten-eleven translocation (TET) enzymes convert 5-mC to 5-hmC. [•] 5hmC can be repaired by thymine DNA glycosylase (TDG). [•] miR-29a targets to Tet1-3 and TDG mRNA and influences global 5hmC. [•] miR-29 can modulate epigenetics by targeting Tets and TDG. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 437
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 89454979
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.06.082