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Oxidized low-density lipoprotein induces hematopoietic stem cell senescence.
- Source :
-
Cell Biology International . 9/1/2013, Vol. 37 Issue 9, p940-948. 9p. - Publication Year :
- 2013
-
Abstract
- We have investigated oxidized low-density lipoprotein (ox-LDL) induced senescence in hematopoietic stem cells (HCs). Mouse Sca-1+ HCs were separated and purified using the magnetic activated cell sorting technique. Ox-LDL induced significant senescence in HCs measured by SA-β-Gal staining, and reduced CFU-Mix colony-forming capacity, arresting cells at G0/G1 phase. In agreement with the cell cycle arrest, ox-LDL markedly reduced the expression of CDK4, cyclin D, and cyclin E. As possible contributing factors for cell senescence, ox-LDL also induced cellular oxidative stress and reduced telomerase activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10656995
- Volume :
- 37
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Cell Biology International
- Publication Type :
- Academic Journal
- Accession number :
- 89399265
- Full Text :
- https://doi.org/10.1002/cbin.10121