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Rates of Behavior and Aging Specified by Mitochondrial Function During Development.
- Source :
-
Science . 12/20/2002, Vol. 298 Issue 5602, p2398-2401. 4p. 1 Chart, 4 Graphs. - Publication Year :
- 2002
-
Abstract
- To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MITOCHONDRIA
*ELECTRON transport
*ADENOSINES
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 298
- Issue :
- 5602
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 8938307
- Full Text :
- https://doi.org/10.1126/science.1077780