Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants.

Highlights: [•] Isopropyl with an amide in PNiPAAm is responsible for its adjuvant potential. [•] Hydrophobic/hydrophilic balance determines adjuvant activity. [•] Dual responsive polymers with collagen can induce an autoimmune response. [•] Boronate polymer with collagen, induced arthritis in the presence of fructose. [•] Continuous release of the polymer bound antigen is essential for adjuvant function. [Copyright &y& Elsevier]