Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole.

Highlights: [•] 31 New Zealand mānuka honeys of varying UMF were analysed for flavonoid content. [•] Pinobanksin, pinocembrin, luteolin and chrysin were 61% of the flavonoid content. [•] 2-formyl-5-(2-methoxyphenyl)-pyrrole, (1), was isolated and characterised. [•] 1 was weakly correlated with non-peroxide antibacterial activity as was luteolin. [•] 1 and luteolin do not have an individual or synergic contribution to bioactivity. [Copyright &y& Elsevier]