Casuarines A and B, Lycopodium alkaloids from Lycopodium casuarinoides.

Authors :: Liu, Fei
Wu, Xing-De
He, Juan
Deng, Xu
Peng, Li-Yan
Luo, Huai-Rong
Zhao, Qin-Shi
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Aug2013, Vol. 54 Issue 34, p4555-4557. 3p.
Publication Year :: 2013
Abstract: Abstract: A phytochemical study on Lycopodium casuarinoides has led to the isolation of two new C16N2-type Lycopodium alkaloids, casuarine A (1), a cage-like structure featured with a fused 6/6/6/6/6 pentacyclic ring system, and casuarine B (2). Their structures were elucidated based on the spectroscopic data and further confirmed by X-ray analysis. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that compound 2 exhibited moderate anti-AChE activity with IC50 46.40μM. [Copyright &y& Elsevier]

Subjects :: *PYRROLES
*CLUB mosses
*ALKALOIDS
*PHYTOCHEMICALS
*ACETYLCHOLINESTERASE inhibitors
*MOLECULAR structure

Language :: English
ISSN :: 00404039
Volume :: 54
Issue :: 34
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 89344528
Full Text :: https://doi.org/10.1016/j.tetlet.2013.06.083