Abnormal changes in voltage-gated sodium channels NaV1.1, NaV1.2, NaV1.3, NaV1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats.

Highlights: [•] Increased VGSCs and CaM but decreased CaMKII were found in hippocampus. [•] Decreased VGSCs and CaM but increased CaMKII were observed in temporal lobe cortex. [•] VGSC proteins appeared in CA1, CA3 and DG of hippocampus and temporal lobe cortex. [•] Co-localizations of VGSCs and CaM were found in hippocampus and temporal lobe cortex. [Copyright &y& Elsevier]