1H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.

Highlights: [•] T1D children were divided according to their level of glycated hemoglobin (HbA1c): below (L-T1D) and above 6.5% (H-T1D). [•] The 1H NMR studies of urine samples including control group were performed together with multivariate and statistical data analysis. [•] The OPLS-DA analysis showed separation between all investigated groups. [•] NMR spectroscopy combined with advance statistical methods can be used as a supporting tool to HbAc1 measurements in T1D diagnosis. [Copyright &y& Elsevier]