Biorelevant solubility of poorly soluble drugs: Rivaroxaban, furosemide, papaverine and niflumic acid.

Highlights: [•] The biorelevant solubility of compounds with different acid–base properties were measured using validated saturation shake-flask method. [•] The precise evaluation of the ionization/solubilization effect on BRM solubility is done. [•] The biorelevant solubility of ampholyte niflumic acid is explained with the microspeciation of the molecule. [•] The relationship between the administration and the biorelevant solubility of drugs is discussed. [Copyright &y& Elsevier]