Novel gel-niosomes formulations as multicomponent systems for transdermal drug delivery.

Highlights: [•] The drugs percutaneous permeation profiles from LC-niosomes formulations as multicomponent systems were investigated. [•] Drugs as third component in the formulations could influence the microstructure of the multicomponent system. [•] Drugs percutaneous permeation from LC-niosomes systems, corresponding niosomal and LC binary systems were compared. [•] All the formulation affected in different way the drugs permeation across the skin. [Copyright &y& Elsevier]