Características electroencefalográficas de niños con trastornos en el desarrollo del lenguaje con y sin histidinemia.

Objective: To describe the electroencephalographic characteristics in children with development language disorders, with and without histidinemia. Methods: An observational, descriptive and transverse investigation was realized in the period of September 2008 until September, 2011, in the service of Clinical Genetic of the Pediatric Hospital "Juan Manuel Márquez", Havana. The sample included 32 patients with development language disorders. Electroencephalographic studies with drug induced sleep were realized to all patients and determinations of levels of serum histidine, by means of the ultramicroanalitic system (SUMA), were realized too. The patients were considered histidinemic children if histidine levels were over 3.76 mg/dl or 242,5 uM. Results: 40, 6 % were histidinemic patients, the masculine sex predominated with 84, 4 % but in males were not frequents high levels of histidinemia. In the feminine sex predominated high levels of histidine. The electroencephalographic activity that prevailed was paroxysmal, with epileptiform discharges in anterior brain regions, for both groups; none of these variables analyzed had statistical significance. The more affected cerebral hemisphere was the left. Conclusions: These electroencephalographic finds do not modify the diagnosis, evolution and rehabilitation that are offered to patients of both groups. For electroencephalogram indication, a precise evaluation is necessary and should be considered other aspects of the clinical method that support a more adequate use of the study. [ABSTRACT FROM AUTHOR]