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3D shape-based analysis of cell line-specific compound response in cancers.

Authors :
He, Ningning
Wang, Xiaoqi
Kim, Nayoung
Lim, Jong-Seok
Yoon, Sukjoon
Source :
Journal of Molecular Graphics & Modelling. Jun2013, Vol. 43, p41-46. 6p.
Publication Year :
2013

Abstract

Highlights: [•] We analyzed selective response of compounds on diverse subset of cancer cell lines. [•] We used GI50 profile of >40,000 compounds on 60 cancer cell lines. [•] 3D shape-based similarity predicts the GI50 profile better than 2D chemical similarity. [•] Lineage- and genotype-specific compound response was identified. [Copyright &y& Elsevier]

Subjects

Subjects :
*CELL lines
*CANCER research
*CANCER cells
*STANDARD deviations
*BIOCHEMICAL mechanism of action
*COEFFICIENTS (Statistics)

Details

Language :
English
ISSN :
10933263
Volume :
43
Database :
Academic Search Index
Journal :
Journal of Molecular Graphics & Modelling
Publication Type :
Academic Journal
Accession number :
89281362
Full Text :
https://doi.org/10.1016/j.jmgm.2013.04.005
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