Modulation of native GABAA receptor activity by triazolo 1,5-benzodiazepines.

Highlights: [•] Synthesis of new 1,5-benzodiazepine derivatives. [•] Use of patch-clamp technique on rat cerebellar granule cells in culture. [•] 1,5-Benzodiazepine derivatives modulate chloride currents activated by GABA. [•] Comparison between 1,4- and 1,5-benzodiazepines effects on GABAA receptor. [ABSTRACT FROM AUTHOR]