New DNA probes to detect aneugenicity in rat bone marrow micronucleated cells by a pan-centromeric FISH analysis.

Authors :: Takeiri, Akira
Motoyama, Shigeki
Matsuzaki, Kaori
Harada, Asako
Taketo, Junko
Katoh, Chiaki
Tanaka, Kenji
Mishima, Masayuki
Source :: Mutation Research - Genetic Toxicology & Environmental Mutagenesis. Jul2013, Vol. 755 Issue 1, p73-80. 8p.
Publication Year :: 2013
Abstract: Highlights: [•] Two novel centromeric satellite sequences were identified in rat genome. [•] All centromeres were detected by mixed FISH probes of rat satellite I, satellite II and satellite III. [•] The method distinguished centromere-positive micronuclei from negative ones. [•] Aneugenic and clastogenic modes of micronucleus induction could be discriminated. [Copyright &y& Elsevier]

Subjects :: *DNA probes
*BONE marrow
*NUCLEOLUS
*SATELLITE DNA
*NUCLEOTIDE sequence
*CENTROMERE
*FLUORESCENCE in situ hybridization
*LABORATORY rats

Language :: English
ISSN :: 13835718
Volume :: 755
Issue :: 1
Database :: Academic Search Index
Journal :: Mutation Research - Genetic Toxicology & Environmental Mutagenesis
Publication Type :: Academic Journal
Accession number :: 89146872
Full Text :: https://doi.org/10.1016/j.mrgentox.2013.05.011

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