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Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions.

Authors :
Kennedy, Colin R.
Tilkens, Sarah B.
Guan, Hong
Garner, Justine A.
Or, Penelope M.Y.
Chan, Andrew M.
Source :
Cancer Letters. Aug2013, Vol. 336 Issue 2, p299-306. 8p.
Publication Year :
2013

Abstract

Highlights: [•] The proliferation of GBM cell lines displayed different sensitivities towards oligomycin or 2DG. [•] Differential sensitivities of GBM cell lines towards oligomycin were correlated with the activation of AMPKα. [•] Combining oligomycin and 2DG has drastic synergistic effects on suppressing cell growth and motility. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
03043835
Volume :
336
Issue :
2
Database :
Academic Search Index
Journal :
Cancer Letters
Publication Type :
Academic Journal
Accession number :
89137501
Full Text :
https://doi.org/10.1016/j.canlet.2013.03.020