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Tetrahydropyrido[d]pyridazinones—promising scaffolds for drug discovery.
- Source :
-
Tetrahedron . Aug2013, Vol. 69 Issue 33, p6799-6803. 5p. - Publication Year :
- 2013
-
Abstract
- Abstract: An approach to the synthesis of all possible tetrahydropyrido[d]pyridazinones has been developed. The method relies on the catalytic hydrogenation of the corresponding aromatic counterparts, which were obtained by cyclization of the relevant dibromomethyl-substituted pyridinecarboxylates with hydrazine. The synthetic schemes include 4–5 steps starting from commercially available materials. The tetrahydropyrido[d]pyridazinone scaffolds are combinations of a saturated heterocycle (piperidine) and a privileged aromatic heterocycle (pyridazinone); hence they are promising starting points for the design in medicinal chemistry. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 69
- Issue :
- 33
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 89136608
- Full Text :
- https://doi.org/10.1016/j.tet.2013.06.029