Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy.

Highlights: [•] Psychopathy arises mainly out of genetic contributions to emotional hyporesponsivity. [•] Sociopathy arises out of interactive gene–environment effects on emotional dysregulation. [•] Enhanced versus dampened serotonergic functionality may define these profiles respectively. [•] High testosterone can increase emotional dysfunctions and the risk for aggression. [Copyright &y& Elsevier]