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Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient.
- Source :
-
Transplant Infectious Disease . Dec2002, Vol. 4 Issue 4, p201-206. 6p. - Publication Year :
- 2002
-
Abstract
- A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GANCICLOVIR
*CYTOMEGALOVIRUS diseases
*BONE marrow transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 13982273
- Volume :
- 4
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Transplant Infectious Disease
- Publication Type :
- Academic Journal
- Accession number :
- 8912593
- Full Text :
- https://doi.org/10.1034/j.1399-3062.2002.02005.x