Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells.

Highlights: [•] We first noted that brazilein inhibited MDA-MB-231 cell migration and invasion. [•] Brazilein suppressed the expression, activation, and mRNA of MMP-2. [•] Brazilein decreased the nuclear protein level of NF-κB. [•] Brazilein suppressed the phosphorylation of p38 MAPK, PI3K and Akt. [Copyright &y& Elsevier]