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Topographical study of O 6-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue.
- Source :
-
Chemico-Biological Interactions . Jul2013, Vol. 204 Issue 2, p98-104. 7p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Geographical variation in susceptibility to alkylating agents in lung investigated. [•] MGMT repair increased towards the lung periphery. [•] Smoking may reduce MGMT repair in central but not peripheral lung tissue. [•] Alkylating agent exposure (N7-meG levels) not related to lung position. [•] No evidence peripheral lung more susceptible to genotoxic alkylating agents. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00092797
- Volume :
- 204
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Chemico-Biological Interactions
- Publication Type :
- Academic Journal
- Accession number :
- 89121985
- Full Text :
- https://doi.org/10.1016/j.cbi.2013.04.013