Nagelamides U–W, bromopyrrole alkaloids from a marine sponge Agelas sp.

Authors :: Tanaka, Naonobu
Kusama, Taishi
Takahashi-Nakaguchi, Azusa
Gonoi, Tohru
Fromont, Jane
Kobayashi, Jun’ichi
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2013, Vol. 54 Issue 29, p3794-3796. 3p.
Publication Year :: 2013
Abstract: Abstract: Three new structurally unique bromopyrrole alkaloids, nagelamides U–W (1–3), were isolated from a marine sponge Agelas sp. Nagelamides U (1) and V (2) possess a γ-lactam ring with an N-ethanesulfonic acid and guanidino moieties, while nagelamide W (3) has two aminoimidazole moieties in the molecule. The structures of 1–3 were elucidated on the basis of spectroscopic data. Nagelamides U (1) and W (3) exhibited antimicrobial activity against Candida albicans. [Copyright &y& Elsevier]

Subjects :: *AMIDES
*PYRROLES
*ALKALOIDS
*SPONGES (Invertebrates)
*SULFONIC acids
*CANDIDA albicans
*ANTI-infective agents
*SPECTRUM analysis

Language :: English
ISSN :: 00404039
Volume :: 54
Issue :: 29
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 89117267
Full Text :: https://doi.org/10.1016/j.tetlet.2013.05.023