MiR-365b-3p, down-regulated in retinoblastoma, regulates cell cycle progression and apoptosis of human retinoblastoma cells by targeting PAX6.

Highlights: [•] MiR-365b-3p is downregulated in human retinoblastoma tissues. [•] MiR-365b-3p inhibits the expression of PAX6 by directly binding its 3′UTR. [•] MiR-365b-3p attenuates cell growth, induces G1 phase arrest and cell apoptosis. [•] MiR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 levels. [ABSTRACT FROM AUTHOR]