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ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.
- Source :
-
DNA Repair . Jul2013, Vol. 12 Issue 7, p500-507. 8p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] DNA damage-response pathway is activated in bone marrow of chronic-phase CML. [•] Loss of one of the allele of Atm accelerates the blast crisis. [•] ATM haploinsufficiency accelerates tumor development when oncogenic event arises. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15687864
- Volume :
- 12
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- DNA Repair
- Publication Type :
- Academic Journal
- Accession number :
- 89113647
- Full Text :
- https://doi.org/10.1016/j.dnarep.2013.04.022