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Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules.

Authors :
Chen, Mei-Chin
Mi, Fwu-Long
Liao, Zi-Xian
Hsiao, Chun-Wen
Sonaje, Kiran
Chung, Min-Fan
Hsu, Li-Wen
Sung, Hsing-Wen
Source :
Advanced Drug Delivery Reviews. Jun2013, Vol. 65 Issue 6, p865-879. 15p.
Publication Year :
2013

Abstract

Abstract: Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0169409X
Volume :
65
Issue :
6
Database :
Academic Search Index
Journal :
Advanced Drug Delivery Reviews
Publication Type :
Academic Journal
Accession number :
89111186
Full Text :
https://doi.org/10.1016/j.addr.2012.10.010