Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection.

Highlights: [•] Severe cases are often observed in patients of 2nd infection with dengue virus. [•] ADE is the hypothesis to explain the mechanism for severe cases 2nd infection. [•] Human monoclonal antibodies to neutralize 1–4 serotypes were prepared. [•] No difference was observed in ADE activities between antibodies from DF and DHF. [Copyright &y& Elsevier]