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Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . May2013, Vol. 23 Issue 9, p2512-2517. 6p. - Publication Year :
- 2013
-
Abstract
- Abstract: APN inhibitors have been considered as potential anticancer agents for years. LB-4b is the first synthetic APN inhibitor to be evaluated for both of its anti-invasion and anti-angiogenesis effects. As a potent synthetic APN inhibitor (IC50 =850nM, versus bestatin of 8.1μM), LB-4b was determined to have more significant block effects to cancer cell invasion and angiogenesis than bestatin. Besides, it is able to be easily synthesized with a high total yield, while the reported synthetic methods of bestatin are much more complex. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 23
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 89068071
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.03.021