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A 1,3-dipolar cycloaddition–annulation protocol for the expedient regio-, stereo- and product-selective construction of novel hybrid heterocycles comprising seven rings and seven contiguous stereocentres.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . May2013, Vol. 54 Issue 20, p2515-2519. 5p. - Publication Year :
- 2013
-
Abstract
- Abstract: An expedient regio-, stereo- and product-selective synthesis of novel hybrid heterocyclic systems comprising [1,2-c]oxazolidine, pyrrolidine and piperidine units, in good to excellent yields, has been developed via three-component 1,3-dipolar cycloaddition/annulation domino reactions and concomitant trifluoroacetic acid mediated condensative annulation with paraformaldehyde. These novel structurally complex heterocyclic hybrids, accessed by a two-step protocol, possess seven rings and seven contiguous stereocentres. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 54
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 89067974
- Full Text :
- https://doi.org/10.1016/j.tetlet.2013.03.021