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Functional magnetic resonance imaging mirrors recovery of visual perception after repetitive tachistoscopic stimulation in patients with partial cortical blindness
- Source :
-
Neuroscience Letters . Jan2003, Vol. 335 Issue 3, p192. 5p. - Publication Year :
- 2003
-
Abstract
- We investigated three patients with partial cortical blindness after brain injury by means of functional magnetic resonance imaging (fMRI) before and after the application of a daily visual stimulation-therapy over a period of 6 months. Before therapy, fMRI data showed a severely reduced blood-oxygen-level-dependent (BOLD) signal in primary visual cortex when compared to healthy volunteers. Following several months of rehabilitative therapy a neuropsychological improvement of visual functions was accompanied by an increase in BOLD signal of residual perilesional regions whereas fMRI data of the control group remained unchanged. A high capacity of functional recovery and synaptic plasticity of surviving perilesional neuronal structures of primary visual cortex followed by an increased input into post-connected visual areas can be discussed as a basis for the reoccurrence of visual functions. [Copyright &y& Elsevier]
- Subjects :
- *MAGNETIC resonance imaging
*BRAIN mapping
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 335
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 8903179
- Full Text :
- https://doi.org/10.1016/S0304-3940(02)01153-9